![]() Moreover, we discuss our own clinical trial experiences on targeted therapies using MSCs in a clinical setting, and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications, with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications. This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy (ISCT). ![]() hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. See a list of all MRFF grant recipients.Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Register with GrantConnect to receive notifications about future funding opportunities under this Mission. View the MRFF grants calendar to see which grants are open, when applications close and when we expect to award funding. The National Health and Medical Research Council (NHMRC) administers this Mission. Our Health and Medical Research Office oversees this and other MRFF initiatives. The Stem Cell Therapies Mission Expert Advisory Panel provides advice to the Minister for Health and Aged Care on the strategic priorities for research investment through the Mission by developing a Roadmap and Implementation Plan. The Medical Research Future Fund (MRFF) funds the Mission. It identifies Stem Cell Therapies Mission projects funded as at March 2023. This is Appendix A to the Medical Research Future Fund (MRFF) Stem Cell Therapies Mission Implementation Plan. The Roadmap and Implementation Plan were published in October 2021 and will be used to develop the Mission’s grant opportunities. See the Stem Cell Therapies Mission Roadmap and Implementation Plan National Consultation Report.īased on the feedback from the international review panel and the national consultation, changes were made to the final Roadmap and Implementation Plan. The draft Roadmap and Implementation Plan also underwent a national consultation between 14 December 2020 and 23 April 2021 to seek community feedback on these documents. See the Stem Cell Therapies Mission International Review of the Roadmap and Implementation Plan. ![]() The draft Roadmap and Implementation Plan were reviewed by an international panel of experts on 20 November 2020 who provided expert feedback and advice in the context of relevant activities occurring internationally. The Stem Cell Therapies Mission Expert Advisory Panel has developed a Roadmap and Implementation Plan to advise the Minister for Health and Aged Care on the strategic priorities for research investment through the Mission. The objective of this Mission is to support world-leading translational stem cell research that develops and delivers innovative, safe and effective stem cell medicines to improve health outcomes, in partnership with patients and carers. Stem cells have the potential to treat many other types of incurable diseases, bringing hope for treatments and cure where previously there was none. Stem cell therapy is a proven treatment for blood disorders such as leukaemia, Hodgkin’s disease and non-Hodgkin’s lymphoma. translate stem cell innovations into commercial products.develop innovative, safe and effective treatments that improve the lives of patients.The Stem Cell Therapies Mission is investing $150 million to develop innovative, safe and effective stem cell therapies to improve health outcomes, in partnership with patients and carers. On this page About the Stem Cell Therapies Mission
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